![]() perforatum has been intensively studied on isolated tissue samples, using animal models and through human clinical trials. Other compounds, including the flavonoids rutin, quercetin, and kaempferol, also appear to have medical activity. Further, SJW produces dozens of biologically active substances, although two-hypericin (a naphthodianthrone) and hyperforin (a lipophilic phloroglucinol)-have the greatest medical activity. Worldwide annual sales of products made from SJW presently exceed several billion dollars. Pharmaceutical companies, particularly in Europe, prepare standard formulations of this herb that are taken by millions of people. Recent research suggests the effectiveness of this herb in treating other ailments, including cancer, inflammation-related disorders, and bacterial and viral diseases, and as an antioxidant and neuroprotective agent. Since then, it has remained a popular treatment for anxiety, depression, cuts, and burns. The use of this species as an herbal remedy to treat a variety of internal and external ailments dates back to the time of the ancient Greeks. John’s wort (SJW), known botanically as Hypericum perforatum, is a sprawling, leafy herb that grows in open, disturbed areas throughout much of the world’s temperate regions.
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